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nbp1  (Novus Biologicals)


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    Novus Biologicals nbp1
    Nbp1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sucnr1+antibody/SUCNR1%2FGPR91+Antibody+-+BSA+Free/pm41746808-232-70-67
    Average 94 stars, based on 22 article reviews
    nbp1 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Incubation:

    Article Title: SUCNR1 is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes
    Article Snippet: .. The cells were blocked in 10% 2nd antibody host serum with 4% BSA in PBS for 1 h at room temperature, followed by overnight incubation at 4 ◦C with SUCNR1 antibody (Novus Biologicals, Littleton, CO, USA). .. The cells were incubated with conjugated 2nd antibody (Invitrogen) for 2 h at room temperature after a washing step.

    Article Title: SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes
    Article Snippet: .. The cells were blocked in 10% 2nd antibody host serum with 4% BSA in PBS for 1 h at room temperature, followed by overnight incubation at 4 °C with SUCNR1 antibody (Novus Biologicals, Littleton, CO, USA). .. The cells were incubated with conjugated 2nd antibody (Invitrogen) for 2 h at room temperature after a washing step.

    In Vivo:

    Article Title: Succinate level is increased and succinate dehydrogenase exerts forward and reverse catalytic activities in lipopolysaccharides-stimulated cardiac tissue: The protective role of dimethyl malonate.
    Article Snippet: This study aimed to investigate the alterations of myocardial succinate and fumarate levels with or without succinate dehydrogenase (SDH) inhibitor dimethyl malonate during 24 h of lipopolysaccharides (LPS) challenge, as well as the effects of dimethyl malonate on the impaired cardiac tissue.. Myocardial succinate and fumarate levels were increased in the initial 9 h of LPS challenge.. During this time, dimethyl malonate increased the succinate level, decreased the fumarate level, aggravated the cardiac dysfunction, reduced the oxidative stress, had little effect on interleukin-1β production, promoted interleukin-10 production and bothered the ATP production.

    Article Title: Pulmonary succinate receptor 1 elevation in high-fat diet mice exacerbates lipopolysaccharides-induced acute lung injury via sensing succinate.
    Article Snippet: Background: Individuals with obesity have higher level of circulating succinate, which acts as a signaling factor that initiates inflammation.. It is obscure whether succinate and succinate receptor 1 (SUCNR1) are involved in the process of obesity aggravating acute lung injury (ALI).. Methods: The lung tissue and blood samples from patients with obesity who underwent lung wedgectomy or segmental resection were collected.

    Activity Assay:

    Article Title: Succinate level is increased and succinate dehydrogenase exerts forward and reverse catalytic activities in lipopolysaccharides-stimulated cardiac tissue: The protective role of dimethyl malonate.
    Article Snippet: This study aimed to investigate the alterations of myocardial succinate and fumarate levels with or without succinate dehydrogenase (SDH) inhibitor dimethyl malonate during 24 h of lipopolysaccharides (LPS) challenge, as well as the effects of dimethyl malonate on the impaired cardiac tissue.. Myocardial succinate and fumarate levels were increased in the initial 9 h of LPS challenge.. During this time, dimethyl malonate increased the succinate level, decreased the fumarate level, aggravated the cardiac dysfunction, reduced the oxidative stress, had little effect on interleukin-1β production, promoted interleukin-10 production and bothered the ATP production.

    Article Title: Pulmonary succinate receptor 1 elevation in high-fat diet mice exacerbates lipopolysaccharides-induced acute lung injury via sensing succinate.
    Article Snippet: Background: Individuals with obesity have higher level of circulating succinate, which acts as a signaling factor that initiates inflammation.. It is obscure whether succinate and succinate receptor 1 (SUCNR1) are involved in the process of obesity aggravating acute lung injury (ALI).. Methods: The lung tissue and blood samples from patients with obesity who underwent lung wedgectomy or segmental resection were collected.



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    a Relative <t>Sucnr1</t> mRNA level between iWAT, eWAT and BAT in WT mice (n = 8 biological replicates). b Relative Sucnr1 mRNA level in iWAT of WT C57BL/6 J mice treated with normal saline, P. copri , or SS uder HFD conditions (n = 7 biological replicates). c-d Western blot analysis (c) and quantification (d) of the protein expression of SUCNR1 in iWAT of WT C57BL/6 J mice, with β-actin serving as a loading control (n = 4 biological replicates). e Experimental scheme in C57BL/6J- Sucnr1 -/- mice for f - s . 8-week-old C57BL/6J- Sucnr1 -/- mice were given normal saline (HFD Control), 10 8 CFU/kg BW P. copri (HFD P. copri ), or 0.25 g/kg BW SS (HFD SS) for 8 weeks under HFD conditions. f Body weight of 16-week-old C57BL/6J- Sucnr1 -/- mice following 8 weeks’ treatment (n = 8 mice). g Representative images of iWAT. h iWAT weight ( n = 8 mice). i Ratio of iWAT weight to body weight ( n = 8 mice). j H&E-stained iWAT sections (Scale bars, 50 μm), (n = 3 biological replicates). k Adipocyte sizes in iWAT ( n = 3 biological replicates). l Rectal body temperature ( n = 8 mice). m–p CO 2 production (m) O 2 consumption (n) RER (o) and heat production (p) curves ( n = 4 mice for HFD Control group, n = 3 mice for HFD P. copri and HFD SS groups), the data were analyzed by covariance (ANCOVA). q Relative mRNA levels of Ucp1 , Tbx1 , Ap2 , and Cpt1 in iWAT of Sucnr1 -/- mice (n = 6 biological replicates). r , s Western blot analysis (r) and quantification (s) of the protein contents of thermogenic and lipogenic markers in iWAT ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with LSD post hoc test for k , Kruskal-Wallis test followed by Dunn’s post hoc test for a , b , d , f , h - i , l , q , s . Source data are provided as a Source Data file.
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    a Relative <t>Sucnr1</t> mRNA level between iWAT, eWAT and BAT in WT mice (n = 8 biological replicates). b Relative Sucnr1 mRNA level in iWAT of WT C57BL/6 J mice treated with normal saline, P. copri , or SS uder HFD conditions (n = 7 biological replicates). c-d Western blot analysis (c) and quantification (d) of the protein expression of SUCNR1 in iWAT of WT C57BL/6 J mice, with β-actin serving as a loading control (n = 4 biological replicates). e Experimental scheme in C57BL/6J- Sucnr1 -/- mice for f - s . 8-week-old C57BL/6J- Sucnr1 -/- mice were given normal saline (HFD Control), 10 8 CFU/kg BW P. copri (HFD P. copri ), or 0.25 g/kg BW SS (HFD SS) for 8 weeks under HFD conditions. f Body weight of 16-week-old C57BL/6J- Sucnr1 -/- mice following 8 weeks’ treatment (n = 8 mice). g Representative images of iWAT. h iWAT weight ( n = 8 mice). i Ratio of iWAT weight to body weight ( n = 8 mice). j H&E-stained iWAT sections (Scale bars, 50 μm), (n = 3 biological replicates). k Adipocyte sizes in iWAT ( n = 3 biological replicates). l Rectal body temperature ( n = 8 mice). m–p CO 2 production (m) O 2 consumption (n) RER (o) and heat production (p) curves ( n = 4 mice for HFD Control group, n = 3 mice for HFD P. copri and HFD SS groups), the data were analyzed by covariance (ANCOVA). q Relative mRNA levels of Ucp1 , Tbx1 , Ap2 , and Cpt1 in iWAT of Sucnr1 -/- mice (n = 6 biological replicates). r , s Western blot analysis (r) and quantification (s) of the protein contents of thermogenic and lipogenic markers in iWAT ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with LSD post hoc test for k , Kruskal-Wallis test followed by Dunn’s post hoc test for a , b , d , f , h - i , l , q , s . Source data are provided as a Source Data file.
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    Image Search Results


    a Relative Sucnr1 mRNA level between iWAT, eWAT and BAT in WT mice (n = 8 biological replicates). b Relative Sucnr1 mRNA level in iWAT of WT C57BL/6 J mice treated with normal saline, P. copri , or SS uder HFD conditions (n = 7 biological replicates). c-d Western blot analysis (c) and quantification (d) of the protein expression of SUCNR1 in iWAT of WT C57BL/6 J mice, with β-actin serving as a loading control (n = 4 biological replicates). e Experimental scheme in C57BL/6J- Sucnr1 -/- mice for f - s . 8-week-old C57BL/6J- Sucnr1 -/- mice were given normal saline (HFD Control), 10 8 CFU/kg BW P. copri (HFD P. copri ), or 0.25 g/kg BW SS (HFD SS) for 8 weeks under HFD conditions. f Body weight of 16-week-old C57BL/6J- Sucnr1 -/- mice following 8 weeks’ treatment (n = 8 mice). g Representative images of iWAT. h iWAT weight ( n = 8 mice). i Ratio of iWAT weight to body weight ( n = 8 mice). j H&E-stained iWAT sections (Scale bars, 50 μm), (n = 3 biological replicates). k Adipocyte sizes in iWAT ( n = 3 biological replicates). l Rectal body temperature ( n = 8 mice). m–p CO 2 production (m) O 2 consumption (n) RER (o) and heat production (p) curves ( n = 4 mice for HFD Control group, n = 3 mice for HFD P. copri and HFD SS groups), the data were analyzed by covariance (ANCOVA). q Relative mRNA levels of Ucp1 , Tbx1 , Ap2 , and Cpt1 in iWAT of Sucnr1 -/- mice (n = 6 biological replicates). r , s Western blot analysis (r) and quantification (s) of the protein contents of thermogenic and lipogenic markers in iWAT ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with LSD post hoc test for k , Kruskal-Wallis test followed by Dunn’s post hoc test for a , b , d , f , h - i , l , q , s . Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Prevotella copri promotes white adipose browning and ameliorates adiposity

    doi: 10.1038/s41467-025-67327-x

    Figure Lengend Snippet: a Relative Sucnr1 mRNA level between iWAT, eWAT and BAT in WT mice (n = 8 biological replicates). b Relative Sucnr1 mRNA level in iWAT of WT C57BL/6 J mice treated with normal saline, P. copri , or SS uder HFD conditions (n = 7 biological replicates). c-d Western blot analysis (c) and quantification (d) of the protein expression of SUCNR1 in iWAT of WT C57BL/6 J mice, with β-actin serving as a loading control (n = 4 biological replicates). e Experimental scheme in C57BL/6J- Sucnr1 -/- mice for f - s . 8-week-old C57BL/6J- Sucnr1 -/- mice were given normal saline (HFD Control), 10 8 CFU/kg BW P. copri (HFD P. copri ), or 0.25 g/kg BW SS (HFD SS) for 8 weeks under HFD conditions. f Body weight of 16-week-old C57BL/6J- Sucnr1 -/- mice following 8 weeks’ treatment (n = 8 mice). g Representative images of iWAT. h iWAT weight ( n = 8 mice). i Ratio of iWAT weight to body weight ( n = 8 mice). j H&E-stained iWAT sections (Scale bars, 50 μm), (n = 3 biological replicates). k Adipocyte sizes in iWAT ( n = 3 biological replicates). l Rectal body temperature ( n = 8 mice). m–p CO 2 production (m) O 2 consumption (n) RER (o) and heat production (p) curves ( n = 4 mice for HFD Control group, n = 3 mice for HFD P. copri and HFD SS groups), the data were analyzed by covariance (ANCOVA). q Relative mRNA levels of Ucp1 , Tbx1 , Ap2 , and Cpt1 in iWAT of Sucnr1 -/- mice (n = 6 biological replicates). r , s Western blot analysis (r) and quantification (s) of the protein contents of thermogenic and lipogenic markers in iWAT ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with LSD post hoc test for k , Kruskal-Wallis test followed by Dunn’s post hoc test for a , b , d , f , h - i , l , q , s . Source data are provided as a Source Data file.

    Article Snippet: The primary antibodies used in this study included UCP1 (sc-293418, Santa Cruz, USA), TBX1 (bs-21501R, Bioss, China), PPARγ (sc-7273, Santa Cruz, USA), AP2 (sc-271529, Santa Cruz, USA), SUCNR1 (AY4281, Abways, China), IL-6 (12912S, CST, USA), p-STAT3 Tyr705 (9145S, CST, USA), STAT3 (4904S, CST, USA), FOXM1 (sc-376471x, Santa Cruz, USA), β-actin (AB0035, Abways, China), and GAPDH (AB0038, Abways, China).

    Techniques: Saline, Western Blot, Expressing, Control, Staining

    a , b Serum IL-6 (a) and TNF-α (b) contents of WT C57BL/6 J mice treated with normal saline, P. copri , or SS ( n = 6 biological replicates). c Relative mRNA levels of inflammation genes in iWAT of WT C57BL/6 J mice ( n = 6 biological replicates for Il-1β , Tnf-α and Tgf-β ; n = 8 biological replicates for Il-6 and Il-33 ). d , e Western blot analysis (d) and quantification (e) of the protein contents of IL-6, p-STAT3, and STAT3 in iWAT of WT C57BL/6 J mice ( n = 6 biological replicates). f Flow cytometry. CD45.2+ represents immune cells; F4/80+ and CD11b+ represent macrophages; CD86+ represents M1 macrophages. g The proportion of F4/80 and CD11b positive cells and MFI of CD86 positive cells ( n = 6 biological replicates). h , i ChIP assay was performed with qPCR to analyze the binding of p-STAT3 to Ucp1 (h) and Tbx1 (i) promoters in iWATDCs ( n = 6 biological replicates). j Experimental scheme for C57BL/6J- Il-6 -/- mice for k-z . 8-week-old C57BL/6J- Il-6 -/- mice were given normal saline (HFD Control) ( n = 6 mice), 10 8 CFU/kg BW P. copri (HFD P. copri ) ( n = 6 mice), or 0.25 g/kg BW SS (HFD SS) ( n = 7 mice) for 8-week under HFD conditions. k Body weight of 16-week-old C57BL/6J- Il-6 -/- mice following 8 weeks’ treatment. l Representative pictures of body composition scanning. m Fat index (%). n Representative images of iWAT. o iWAT weight. p Ratio of iWAT weight to body weight. q H&E-stained iWAT sections (Scale bars, 50 μm), ( n = 3 biological replicates). r Adipocyte sizes in iWAT ( n = 3 biological replicates). s Rectal body temperature ( n = 6 mice for HFD Control and HFD P. copri group; n = 7 mice for HFD SS group). t–w CO 2 production (t) O 2 consumption (u) RER (v) , and heat production (w) curves ( n = 3 mice for HFD Control and HFD P. copri groups and n = 4 mice for HFD SS group), the data were analyzed by covariance (ANCOVA). x Relative mRNA levels of lipid metabolism-related genes in iWAT of C57BL/6J- Il-6 -/- mice ( n = 5 biological replicates for Il-6 -KO-HFD P. copri group; n = 5 biological replicates for Il-6 -KO-HFD Control and Il-6 -KO-HFD SS groups of Hsl ; n = 6 biological replicates for Il-6 -KO-HFD Control and Il-6 -KO-HFD SS groups of Ucp1 , Tbx1 , Ap2 , Lpl , Fas , Cpt1 and Sucnr1 ). y , z Western blot analysis (y) and quantification (z) of related proteins ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with Dunnett’s T3 post hoc test for Il-6 of c , Kruskal-Wallis test followed by Dunn’s post hoc test for a-b , Il-1β, Tnf-α , Il-33 and Tgf-β of c , e , g–i , k , m , o–p, r-s , x , z . Source data are provided as a file.

    Journal: Nature Communications

    Article Title: Prevotella copri promotes white adipose browning and ameliorates adiposity

    doi: 10.1038/s41467-025-67327-x

    Figure Lengend Snippet: a , b Serum IL-6 (a) and TNF-α (b) contents of WT C57BL/6 J mice treated with normal saline, P. copri , or SS ( n = 6 biological replicates). c Relative mRNA levels of inflammation genes in iWAT of WT C57BL/6 J mice ( n = 6 biological replicates for Il-1β , Tnf-α and Tgf-β ; n = 8 biological replicates for Il-6 and Il-33 ). d , e Western blot analysis (d) and quantification (e) of the protein contents of IL-6, p-STAT3, and STAT3 in iWAT of WT C57BL/6 J mice ( n = 6 biological replicates). f Flow cytometry. CD45.2+ represents immune cells; F4/80+ and CD11b+ represent macrophages; CD86+ represents M1 macrophages. g The proportion of F4/80 and CD11b positive cells and MFI of CD86 positive cells ( n = 6 biological replicates). h , i ChIP assay was performed with qPCR to analyze the binding of p-STAT3 to Ucp1 (h) and Tbx1 (i) promoters in iWATDCs ( n = 6 biological replicates). j Experimental scheme for C57BL/6J- Il-6 -/- mice for k-z . 8-week-old C57BL/6J- Il-6 -/- mice were given normal saline (HFD Control) ( n = 6 mice), 10 8 CFU/kg BW P. copri (HFD P. copri ) ( n = 6 mice), or 0.25 g/kg BW SS (HFD SS) ( n = 7 mice) for 8-week under HFD conditions. k Body weight of 16-week-old C57BL/6J- Il-6 -/- mice following 8 weeks’ treatment. l Representative pictures of body composition scanning. m Fat index (%). n Representative images of iWAT. o iWAT weight. p Ratio of iWAT weight to body weight. q H&E-stained iWAT sections (Scale bars, 50 μm), ( n = 3 biological replicates). r Adipocyte sizes in iWAT ( n = 3 biological replicates). s Rectal body temperature ( n = 6 mice for HFD Control and HFD P. copri group; n = 7 mice for HFD SS group). t–w CO 2 production (t) O 2 consumption (u) RER (v) , and heat production (w) curves ( n = 3 mice for HFD Control and HFD P. copri groups and n = 4 mice for HFD SS group), the data were analyzed by covariance (ANCOVA). x Relative mRNA levels of lipid metabolism-related genes in iWAT of C57BL/6J- Il-6 -/- mice ( n = 5 biological replicates for Il-6 -KO-HFD P. copri group; n = 5 biological replicates for Il-6 -KO-HFD Control and Il-6 -KO-HFD SS groups of Hsl ; n = 6 biological replicates for Il-6 -KO-HFD Control and Il-6 -KO-HFD SS groups of Ucp1 , Tbx1 , Ap2 , Lpl , Fas , Cpt1 and Sucnr1 ). y , z Western blot analysis (y) and quantification (z) of related proteins ( n = 3 biological replicates). Values are mean ± SEM. Statistical analysis was performed using One-way ANOVA with Dunnett’s T3 post hoc test for Il-6 of c , Kruskal-Wallis test followed by Dunn’s post hoc test for a-b , Il-1β, Tnf-α , Il-33 and Tgf-β of c , e , g–i , k , m , o–p, r-s , x , z . Source data are provided as a file.

    Article Snippet: The primary antibodies used in this study included UCP1 (sc-293418, Santa Cruz, USA), TBX1 (bs-21501R, Bioss, China), PPARγ (sc-7273, Santa Cruz, USA), AP2 (sc-271529, Santa Cruz, USA), SUCNR1 (AY4281, Abways, China), IL-6 (12912S, CST, USA), p-STAT3 Tyr705 (9145S, CST, USA), STAT3 (4904S, CST, USA), FOXM1 (sc-376471x, Santa Cruz, USA), β-actin (AB0035, Abways, China), and GAPDH (AB0038, Abways, China).

    Techniques: Saline, Western Blot, Flow Cytometry, Binding Assay, Control, Staining

    People with obesity have aberrantly low abundance of P. copri in their fecal microbiomes. In HFD-fed mice, oral P. copri administration increased iWAT browning and attenuated weight gain via its metabolite, succinate, in a manner largely dependent on activation of the macrophage SUCNR1-FOXM1-IL-6- STAT3 axis. The macrophage-derived IL-6-STAT3 pathway, triggered by FOXM1-mediated Il-6 transcription, was essential for this P. copri- or succinate-inducible iWAT browning (Created by figdraw.com. Shuang Liu. (2025) Copyright Code: TTSUP444f8).

    Journal: Nature Communications

    Article Title: Prevotella copri promotes white adipose browning and ameliorates adiposity

    doi: 10.1038/s41467-025-67327-x

    Figure Lengend Snippet: People with obesity have aberrantly low abundance of P. copri in their fecal microbiomes. In HFD-fed mice, oral P. copri administration increased iWAT browning and attenuated weight gain via its metabolite, succinate, in a manner largely dependent on activation of the macrophage SUCNR1-FOXM1-IL-6- STAT3 axis. The macrophage-derived IL-6-STAT3 pathway, triggered by FOXM1-mediated Il-6 transcription, was essential for this P. copri- or succinate-inducible iWAT browning (Created by figdraw.com. Shuang Liu. (2025) Copyright Code: TTSUP444f8).

    Article Snippet: The primary antibodies used in this study included UCP1 (sc-293418, Santa Cruz, USA), TBX1 (bs-21501R, Bioss, China), PPARγ (sc-7273, Santa Cruz, USA), AP2 (sc-271529, Santa Cruz, USA), SUCNR1 (AY4281, Abways, China), IL-6 (12912S, CST, USA), p-STAT3 Tyr705 (9145S, CST, USA), STAT3 (4904S, CST, USA), FOXM1 (sc-376471x, Santa Cruz, USA), β-actin (AB0035, Abways, China), and GAPDH (AB0038, Abways, China).

    Techniques: Activation Assay, Derivative Assay